Epigraph: A Vaccine Design Tool Applied to an HIV Therapeutic Vaccine and a Pan-Filovirus Vaccine

Epigraph: A Vaccine Design Tool Applied to an HIV Therapeutic Vaccine and a Pan-Filovirus Vaccine

Epigraph is an efficient graph-based algorithm for designing vaccine antigens to optimize potential T-cell epitope (PTE) coverage. Epigraph vaccine antigens are functionally similar to Mosaic vaccines, which have demonstrated effectiveness in preliminary HIV non-human primate studies. In contrast to the Mosaic algorithm, Epigraph is substantially faster, and in restricted cases, provides a math...

Design and tests of an HIV vaccine.

It is likely that a successful vaccine against HIV will need to stimulate the innate immune system, generate high levels of neutralising antibody, strong cellular immune responses, and mucosal immunity. Early efforts to develop HIV vaccines attempted to use the virus glycoprotein, gp120, to induce neutralising antibody, but did not take into account the trimeric structure of the native glycopro...

Anti-Carbohydrate HIV Vaccine Design

R. Pantophlet (ed.), HIV Glycans in Infection and Immunity, DOI 10.1007/978-1-4614-8872-9_6, © Springer Science+Business Media New York 2014 Abstract HIV has evolved a number of strong defense mechanisms, including extensive glycosylation of its surface envelope glycoprotein, to evade host immune responses. Nevertheless, the discovery of a series of glycan-dependent broadly neutralizing antibod...

Towards a Pan-Anti-Allergy Vaccine

Allergic manifestations affect 20% 30% of the population in industrialized countries. The global market for asthma and allergy medications has been estimated to exceed USD 6 billion, since 40% of the human population has some form of IgE sensitization to diverse proteins. Most therapeutic intervention strategies cope with the symptoms of allergy without eliminating the underlying cause and many...

A Strategy for Developing an HIV Vaccine